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INDICATIONS AND CLINICAL USE

VALIUM (diazepam) is useful in the symptomatic management of mild to moderate degrees of
anxiety in conditions dominated by tension, excitation, agitation, fear or aggressiveness, such as
may occur in: psychoneurosis, anxiety reactions due to stress conditions and anxiety states with
somatic expression. Buy Valium roche 10mg, Diazepam 5mg for sale online in Australia

In acute alcoholic withdrawal, VALIUM may be useful in the symptomatic relief of acute
agitation, tremor and impending acute delirium tremens.
VALIUM is a useful adjunct for the relief of skeletal muscle spasm due to reflex spasm to local
pathology, such as inflammation of the muscle and joints or secondary to trauma; spasticity
caused by upper motor neuron disorders, such as cerebral palsy and paraplegia; athetosis and the
rare “stiff man syndrome”. Buy Valium roche 10mg, Diazepam 5mg for sale online in Australia

Geriatrics
Elderly and debilitated patients are especially susceptible to dose-related adverse events and a
reduced dose is recommended. Long-term use of VALIUM should be avoided in elderly patients.
Enhanced monitoring is recommended (see WARNINGS AND PRECAUTIONS, Falls and
fractures; DOSAGE AND ADMINISTRATION, Dosing considerations).
Pediatrics
VALIUM is contraindicated in children under 6 months (see CONTRAINDICATIONS and
DOSAGE AND ADMINISTRATION, Children). Buy Valium roche 10mg, Diazepam 5mg for sale online in Australia

Serious Warnings and Precautions
Addiction, Abuse and Misuse
The use of benzodiazepines, including VALIUM, can lead to abuse, misuse, addiction, physical
dependence and withdrawal reactions. Abuse and misuse can result in overdose or death,
especially when benzodiazepines are combined with other medicines, such as opioids, alcohol or
illicit drugs.
• Assess each patient’s risk prior to prescribing VALIUM
• Monitor all patients regularly for the development of these behaviours or conditions.
• VALIUM should be stored securely to avoid theft or misuse.
Withdrawal
Benzodiazepines, like VALIUM, can produce severe or life-threatening withdrawal symptoms.
• Avoid abrupt discontinuation or rapid dose reduction of VALIUM.
• Terminate treatment with VALIUM by gradually tapering the dosage schedule under close
monitoring. Buy Valium roche 10mg, Diazepam 5mg for sale online in Australia
(see WARNINGS AND PRECAUTIONS, Dependence/Tolerance)
Risks from Concomitant use with Opioids
Concomitant use of VALIUM and opioids may result in profound sedation, respiratory
depression, coma and death (see WARNINGS AND PRECAUTIONS, General, Concomitant
use with opioids).
• Reserve concomitant prescribing of these drugs for use in patients for whom alternative
treatment options are not possible.
• Limit dosages and durations to the minimum required.
• Follow patients for signs and symptoms of respiratory depression and sedation

General. Buy Valium roche 10mg, Diazepam 5mg for sale online in Australia
Benzodiazepines are only indicated when the disorder is severe, disabling or subjecting the
individual to extreme distress.
Page 5 of 32
Benzodiazepines are not recommended for the primary treatment of psychotic illness.
Benzodiazepines should not be used alone to treat depression or anxiety associated with
depression as suicide may occur in such patients. Patients with a history of depression and/or
suicide attempts should be kept under close supervision.
Anterograde amnesia may occur with therapeutic doses of benzodiazepines and may be
associated with inappropriate behaviour, the risk increasing with higher doses (see ADVERSE
REACTIONS). Buy Valium roche 10mg, Diazepam 5mg for sale online in Australia
Concomitant use with opioids
Concomitant use of benzodiazepines, including VALIUM, and opioids may result in profound
sedation, respiratory depression, coma and death. Because of these risks, reserve concomitant
prescribing of these drugs for use in patients for whom alternative treatment options are not
possible (see SERIOUS WARNINGS AND PRECAUTIONS BOX, Risks from Concomitant
use with Opioids; DRUG INTERACTIONS, Serious Drug Interactions).
Observational studies have demonstrated that concomitant use of opioid analgesics and
benzodiazepines increases the risk of drug-related mortality compared to use of opioid analgesics
alone. Because of similar pharmacological properties, it is reasonable to expect similar risk with
the concomitant use of other central nervous system (CNS) depressant drugs with
benzodiazepines. Buy Valium roche 10mg, Diazepam 5mg for sale online in Australia
If a decision is made to prescribe VALIUM concomitantly with opioids, prescribe the lowest
effective dosages and minimum durations of concomitant use. In patients already receiving an
opioid analgesic, prescribe a lower initial dose of VALIUM than indicated, and titrate based on
clinical response. If an opioid analgesic is initiated in a patient already taking VALIUM,
prescribe a lower initial dose of the opioid analgesic and titrate based on clinical response.
Follow patients closely for signs and symptoms of respiratory depression and sedation (see
OVERDOSAGE). Buy Valium roche 10mg, Diazepam 5mg for sale online in Australia
Advise both patients and caregivers about the risks of respiratory depression and sedation when
VALIUM is used with opioids.
Advise patients not to drive or operate heavy machinery until the effects of concomitant use of
the opioid have been determined. Buy Valium roche 10mg, Diazepam 5mg for sale online in Australia
Concomitant use of alcohol and/or centrally acting depressants
The concomitant use of VALIUM with alcohol and/or CNS depressants should be avoided. Such
concomitant use has the potential to increase the clinical effects of VALIUM possibly including
severe sedation, that could result in coma or death, clinically relevant respiratory and/or
cardiovascular depression (see DRUG INTERACTIONS and OVERDOSE).
Patients should be advised against the concurrent use of VALIUM with alcohol and/or other
CNS depressant drugs. Buy Valium roche 10mg, Diazepam 5mg for sale online in Australia