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Intravenous
Myxoedema coma

Oral
Hypothyroidism

Oral
T3 suppression test

May be taken with or without food. Buy Tertroxin Online, Liothyronine for sale in Australia

Uncorrected adrenal insufficiency or untreated thyrotoxicosis, acute MI or angina of effort; artificial rewarming (IV).

Patients with adrenal insufficiency, myxoedema, severe and long-standing hypothyroidism; diabetes mellitus or diabetes insipidus; CV disease including angina, coronary artery disease and hypertension. Renal impairment. Children and elderly. Pregnancy and lactation.

Significant: Osteoporosis, MI, poor glycaemic control.
Cardiac disorders: Angina, arrhythmia, cardiac failure, tachycardia.
Gastrointestinal disorders: Diarrhoea, abdominal cramps, vomiting.
General disorders and administration site conditions: Fever, heat intolerance.
Immune system disorders: Hypersensitivity including (e.g. angioedema, urticaria). Buy Tertroxin Online, Liothyronine for sale in Australia
Injury, poisoning and procedural complications: Phlebitis.
Investigations: Weight loss.
Metabolism and nutrition disorders: Increased appetite.
Musculoskeletal and connective tissue disorders: Muscle weakness and cramps, twitching.
Nervous system disorders: Excitability, headache, tremors.
Psychiatric disorders: Anxiety, insomnia, nervousness, restlessness.
Reproductive system and breast disorders: Menstrual irregularities, impaired fertility.
Skin and subcutaneous tissue disorders: Excessive sweating, pruritus, rash, hair loss.
Vascular disorders: Flushing, hypotension, hypertension.
Potentially Fatal: Cardiopulmonary arrest. Buy Tertroxin Online, Liothyronine for sale in Australia

IV/Parenteral/PO: A

Monitor TSH and triiodothyronine (T₃) levels periodically during therapy; signs of hypo- or hyperthyroidism. Monitor thyroid function test (FT₄, T₃, T₄) every 1-2 days in patients with myxoedema coma. Monitor cardiac function including blood pressure, heart rate, electrical activity (ECG) and recent or aggravated cardiac symptoms (e.g. chest pain, palpitations) regularly. Obtain bone mineral density test especially in postmenopausal women. Buy Tertroxin Online, Liothyronine for sale in Australia

Symptoms: Anxiety, heat intolerance, insomnia, irritability, menstrual irregularities, nervousness, palpitation, sweating, tachycardia, tremors, weight loss, angina, arrhythmia, acute myocardial infarction, CHF,  fever, shock (if with untreated pituitary or adrenocortical failure), convulsions, coma. Management: Reduce dose or withdraw therapy temporarily. Symptomatic and supportive treatment. May perform gastric lavage, induce emesis, administer activated charcoal and correct electrolyte and fluid imbalances. Administration of β-blocker for the treatment of increased sympathetic activity and anticonvulsants for severe cases may be considered. Buy Tertroxin Online, Liothyronine for sale in Australia

Increases serum plasma concentration of phenytoin. Increases the effect of oral anticoagulants (e.g. coumarin, phenindione) and sympathomimetic agents (e.g. epinephrine). May decrease the serum concentration of cardiac glycosides (e.g. digoxin). Decreased gastrointestinal absorption with bile acid sequestrants (e.g. colestyramine, colestipol). Decreased serum plasma concentration with carbamazepine, phenytoin. Decreased effect with oral contraceptives amiodarone, sertraline. Enhanced metabolism if concurrently administered with barbiturates (e.g. phenobarbital), primidone and rifampicin. Enhances receptor sensitivity to catecholamines when concurrently administered with TCAs (e.g. amitriptyline) resulting in increased risk for toxicity such as cardiac arrhythmias. Increased risk of hypertension and tachycardia when concurrently administered with ketamine. May alter the requirements of antidiabetic drugs. Accelerates the metabolism of β-blockers (e.g. propranolol). Buy Tertroxin Online, Liothyronine for sale in Australia

May alter thyroid function tests.

Description: Liothyronine is involved in increasing the basal metabolic rate of carbohydrates, fats and proteins; regulation and differentiation of cell growth. It acts on DNA by entering the cell followed by attaching itself to thyroid receptor proteins, resulting in a hormone nuclear receptor complex. This complex is then responsible in activating gene transcription while synthesising messenger RNA and cytoplasmic proteins.
Onset: 2-4 hours (IV). Buy Tertroxin Online, Liothyronine for sale in Australia
Pharmacokinetics:
Absorption: Adequately absorbed (about 95%) from the gastrointestinal tract.
Distribution: Binds to thyroxine-binding globulin (TBG) and some extent to thyroxine-binding pre-albumin (TBPA) or albumin. Enters breast milk (low amounts).
Metabolism: Metabolised in the liver via deiodination into inactive di-iodothyronine and mono-iodothyronine; also via conjugation with glucuronides and sulfates into metabolites that undergo enterohepatic recirculation in the bile and gut.
Excretion: Mainly via urine; remainder via faeces. Elimination half-life: 1-2 days (euthyroidism).

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 5920, Liothyronine. https://pubchem.ncbi.nlm.nih.gov/compound/Liothyronine. Accessed Oct. 26, 2020.

Tab: Store between 15-30°C. Solution for inj: Store between 2-8°C. Storage recommendations may vary among countries or individual products. Refer to specific product guidelines.