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Treatment of moderate to severe pain in patients with cancer and postoperative pain. Treatment of severe pain requiring the use of a strong opioid.

For IV or SC injection or infusion only.
The dose should be adjusted according to the severity of pain, the total condition of the patient and previous or concurrent medication.
Adult >18 years: The following starting doses are recommended. A gradual increase in dose may be required if analgesia is inadequate or if pain severity increases.
Intravenous (Bolus): Dilute to 1 mg/mL in 0.9% saline, 5% dextrose or water for injections. Administer a bolus dose of 1-10 mg slowly over 1-2 min.
Doses should not be administered more frequently than every 4 hrs.
Intravenous (Infusion): Dilute 1 mg/mL in 0.9% saline, 5% dextrose or water for injections. Recommended Starting Dose: 2 mg/hr.
Intravenous (PCA): Dilute to 1 mg/mL in 0.9% saline, 5% dextrose or water for injections. Bolus doses of 0.03 mg/kg should be administered with a minimum lock-out time of 5 min. Buy Oxynorm 10mg 20mg, for sale online without script online Australia
Subcutaneous (Bolus): Use as 10 mg/mL concentration. Recommended Starting Dose: 5 mg repeated at 4-hrly intervals as required.
Subcutaneous (Infusion): Dilute in 0.9% saline, 5% dextrose or water for injections if required. Recommended Starting Dose: 7.5 mg/mL in opioid naive patients, titrating gradually according to symptom control. Cancer patients transferring from oral oxycodone may require much higher doses (see following text).
Transferring Patients Between Oral and Parenteral Oxycodone: The dose should be based on the following ratio: 2 mg of oral oxycodone is equivalent to 1 mg of parenteral oxycodone. It must be emphasized that this is a guide to the dose required. Interpatient variability requires that each patient is carefully titrated to the appropriate dose. Buy Oxynorm 10mg 20mg, for sale online without script online Australia
Patients with Renal and Hepatic Impairment: Patients with mild to moderate renal impairment and/or mild hepatic impairment should be treated with caution. The lowest dose should be given with careful titration to pain control.
Nonmalignant Pain: Opioids are not 1st-line therapy for chronic nonmalignant pain, nor are they recommended as the only treatment. Types of chronic pain which have been shown to be alleviated by strong opioids include chronic osteoarthritic pain and intervertebral disc disease. The need for continued treatment in nonmalignant pain should be assessed at regular intervals.
Cessation of Therapy: When a patient no longer requires therapy with oxycodone, it may be advisable to taper the dose gradually to prevent symptoms of withdrawal. Buy Oxynorm 10mg 20mg, for sale online without script online Australia
Elderly: Elderly patients should be treated with caution. The lowest dose should be administered with careful titration to pain control.

Symptoms: Signs of oxycodone toxicity and overdosage are pinpoint pupils, respiratory depression, hypotension and hallucinations. Nausea and vomiting are common in less severe cases. Noncardiac pulmonary oedema and rhabdomyolysis are particularly common after IV injection of opioid analgesics. Circulatory failure and somnolence progressing to stupor or coma, skeletal muscle flaccidity, bradycardia and death may occur in more severe cases. Buy Oxynorm 10mg 20mg, for sale online without script online Australia
The effects of overdosage will be potentiated by the simultaneous ingestion of alcohol or other psychotropic drugs.
Treatment: Primary attention should be given to the establishment of a patent airway and institution of assisted or controlled ventilation.
In the case of massive overdosage, administer naloxone IV (0.4-2 mg for an adult and 0.01 mg/kg body weight for children) if the patient is in a coma or respiratory depression is present. Repeat the dose at 2-min intervals if there is no response. If repeated doses are required, then an infusion of 60% of the initial doses/hr is a useful starting point. A solution of 10 mg made up in 50 mL dextrose will produce 200 mcg/mL for infusion using an IV pump (dose adjusted to the clinical response). Infusions are not a substitute for frequent review of the patients clinical state.
Naloxone IM is an alternative in the event that IV access is not possible. As the duration of action of naloxone is relatively short, the patient must be carefully monitored until spontaneous respiration is reliably re-established. Naloxone is a competitive antagonist and large doses (4 mg) may be required in seriously poisoned patients. Buy Oxynorm 10mg 20mg, for sale online without script online Australia
For less severe overdosage, administer naloxone 0.2 mg IV followed by increments of 0.1 mg every 2 min if required.
The patient should be observed for at least 6 hrs after the last dose of naloxone.
Naloxone should not be administered in the absence of clinically significant respiratory or circulatory depression secondary to oxycodone overdosage. Naloxone should be administered cautiously to persons who are known or suspected to be physically dependent on oxycodone. In such cases, an abrupt or complete reversal of opioid effects may precipitate pain and an acute withdrawal syndrome. Buy Oxynorm 10mg 20mg, for sale online without script online Australia