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Indications and Dosage. Buy Clomid online, for sale in Australia Oral
Anovulatory infertility Adult: 50 mg once daily for 5 days, starting at any time if there is no uterine bleeding or on the 5th day of the menstrual cycle. If ovulation does not occur w/in 5-10 days, a 2nd course of 100 mg once daily for 5 days may be given, starting as early as 30 days after the previous course. Max: 3 courses.
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Hepatic Impairment
Contraindicated.
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Administration
May be taken with or without food. Buy Clomid online, for sale in Australia
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Contraindications
Abnormal uterine bleeding of unknown origin, ovarian cyst or enlargement not due to polycystic ovarian syndrome, organic intracranial lesion (e.g. pituitary tumour), uncontrolled thyroid or adrenal dysfunction. Active liver disease or history of hepatic impairment. Pregnancy.
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Special Precautions
Patient w/ uterine fibroids, polycystic ovarian syndrome (PCOS). Lactation.
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Adverse Reactions
Significant: Mild to moderate OHSS, visual disturbance (e.g. blurring, scotomata, diplopia, photophobia), endometriosis, ovarian enlargement and cyst formation, risk of multiple or ectopic pregnancy. Rarely, risk of borderline or invasive ovarian cancer.
Nervous: Headache, convulsion, restlessness, insomnia, dizziness, vertigo, lightheadedness, depression, nervous tension, fatigue, insomnia. GI: Nausea, vomiting, constipation, diarrhoea, increased appetite. Buy Clomid online, for sale in Australia Genitourinary: Increased urinary frequency and volume, vag dryness, menorrhagia, uterine haemorrhage, endometriosis. Endocrine: Vasomotor flushes, hypertriglyceridemia, wt gain. Dermatologic: Urticaria, rash, dermatitis, hair loss and dryness. Others: Breast discomfort. Potentially Fatal: Severe OHSS manifesting as gross ovarian enlargement, pericardial effusion, severe abdominal pain, ascites, dyspnoea, acute resp distress syndrome, hypotension, tachycardia, thromboembolism, hypovolemic shock, and haemoconcentration. Buy Clomid online, for sale in Australia |
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Patient Counseling Information
This drug may cause visual disturbances, dizziness, and lightheadedness, if affected, do not drive or operate machinery.
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Monitoring Parameters
Monitor serum oestrogen prior to therapy. Perform pelvic exam and endometrial biopsy before each course and pregnancy test prior to repeat courses. Monitor for ovulation through basal body temp, ultrasound, serum progesterone, oestradiol, and urinary LH. Assess signs and symptoms of ovarian hyperstimulation syndrome (OHSS). Buy Clomid online, for sale in Australia
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Overdosage
Symptoms: Nausea, vomiting, vasomotor flashes, blurring of vision, scotomata, ovarian enlargement w/ pelvic or abdominal pain. Management: Supportive treatment. Perform GI decontamination.
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Drug Interactions
May enhance adverse effect of ospemifene. Buy Clomid online, for sale in Australia
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Action
Description: Clomifene is a nonsteroidal compound that has both oestrogenic and anti-oestrogenic effects. It stimulates ovulation by inhibiting the negative feedback effect of oestrogens at receptor sites in the hypothalamus and pituitary, thereby increasing hypothalamic GnRH secretion w/ subsequent release of pituitary FSH and LH.
Onset: 5-10 days. Pharmacokinetics: Absorption: Readily absorbed from the GI tract. Time to peak plasma concentration: Approx 6 hr. Metabolism: Metabolised in the liver; undergoes enterohepatic recirculation. Excretion: Via faeces (42%) and urine (8%). Elimination half-life: Approx 5 days. Buy Clomid online, for sale in Australia |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Database. Clomiphene, CID=1548953, https://pubchem.ncbi.nlm.nih.gov/compound/Clomiphene (accessed on Jan. 21, 2020) |
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Storage
Store below 25°C. Protect from light, heat, and excessive humidity.
Use appropriate personal protective equipment (e.g. gloves) for receiving, handling, admin and disposal. |
| Quantity | 100 Tablets, 200 Tablets, 500 Tablets |
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