Buy Apo Diazepam online

Oral
Insomnia associated with anxiety

Oral
Adjunct in seizures

Oral
Premedication before anaesthesia, Sedation in minor surgical and medical procedures

Oral
Muscle spasms

Oral
Severe anxiety

Oral
Alcohol withdrawal syndrome

Parenteral
Severe anxiety

Parenteral
Muscle spasms

Parenteral
Premedication before anaesthesia

Parenteral
Alcohol withdrawal syndrome

Parenteral
Seizures

Rectal
Adjunct in seizures

Rectal
Muscle spasms, Premedication before anaesthesia, Sedation in minor surgical and medical procedures, Severe anxiety

Debilitated patients: Initially, 2-2.5 mg 1-2 times daily, increase gradually as needed and tolerated.

Pharmacogenomics:

Diazepam is mainly metabolised in the liver by CYP2C19 and CYP3A4 to its major active metabolite, desmethyldiazepam, and two minor active metabolites, temazepam and oxazepam. According to a study, approx 3% of Caucasians and 15-20% of Asians are poor metabolisers of CYP2C19 or have decreased or absent CYP2C19 enzyme activity. Available references suggest that genetic polymorphism of CYP2C19 gene may affect the pharmacokinetics of diazepam and emergence from general anaesthesia of the patient. Buy Apo Diazepam 5mg, valium for sale online in Australia

For patients receiving diazepam to relieve preoperative anxiety:

CYP2C19 extensive metabolisers (e.g. *1/*1)
Increased metabolism of diazepam and more rapid emergence from anaesthesia than intermediate or poor metabolisers have been reported.

CYP2C19 intermediate metabolisers (e.g. *1/*2 or *1/*3)
Increased metabolism of diazepam has been reported and recovery from anaesthesia may be prolonged.

CYP2C19 poor metabolisers (e.g. *2/*2, *3/*3 or *2/*3)
Decreased metabolism and reduced plasma clearance of diazepam have been reported. Studies suggest that patient may emerge from anaesthesia less rapidly than extensive metabolisers. No dosage adjustment needed. Buy Apo Diazepam 5mg, valium for sale online in Australia

Oral:
Severe anxiety; Insomnia associated with anxiety; Muscle spasms; Adjunct in seizures; Alcohol withdrawal syndrome; Premedication before anaesthesia; Sedation in minor surgical and medical procedures:
Severe: Reduce dose.

Reduce dose. Severe: Contraindicated.

May be taken with or without food.

Do not mix IV product with other medications in the same infusion solution or syringe.

Acute or chronic severe respiratory insufficiency, respiratory depression, myasthenia gravis, sleep apnoea, severe hepatic insufficiency, acute narrow-angle glaucoma, phobic or obsessional states, chronic psychosis, hyperkinesis, acute porphyria. Avoid alcohol. Infants <6 months.

Patient with convulsive disorder, history of alcoholism and/or drug abuse open-angle glaucoma, cardiorespiratory insufficiency, chronic respiratory insufficiency, ataxic, obese, and debilitated patient; neurologic damage (rectal). Avoid abrupt withdrawal. CYP2C19 extensive, intermediate and poor metabolisers. Renal and mild to moderate hepatic impairment. Children and elderly. Pregnancy and lactation. Not intended as monotherapy in patients with depression, anxiety as suicide may be precipitated in such patients. Buy Apo Diazepam 5mg, valium for sale online in Australia

Significant: Withdrawal symptoms (e.g. rebound insomnia and anxiety, panic, palpitations, sweating, paranoid psychosis, epileptic attacks, delirium), anterograde amnesia, paradoxical reactions (e.g. restlessness, agitation, irritability, aggressiveness, delusion, rages, nightmares, psychoses), habituation, drug dependence.
Eye disorders: Blurred vision, diplopia.
Gastrointestinal disorders: Constipation, nausea, gastrointestinal disturbances, altered salivation.
General disorders and admin site conditions: Fatigue, ataxia, local reactions at the injection site e.g. thrombophlebitis and venous thrombosis.
Investigations: Elevated transaminases and alkaline phospahatase.
Nervous system disorders: Impaired motor ability, tremor, headache, vertigo.
Psychiatric disorders: Confusion, depression, slurred speech.
Renal and urinary disorders: Urinary incontinence, urinary retention.
Reproductive system and breast disorders: Change in libido. Buy Apo Diazepam 5mg, valium for sale online in Australia
Vascular disorders: Hypotension.

IM/IV/Parenteral/PO/Rectal: D

This drug may cause CNS depression (e.g. sedation, amnesia, impaired concentration, dizziness, drowsiness), blurred vision and impaired muscular function, if affected, do not drive or operate machinery.

Monitor heart rate, respiratory rate, blood pressure, mental state, liver enzymes and CBC. Assess for history of addiction; signs and symptoms of dependence, abuse, or tolerance for long-term use. Buy Apo Diazepam 5mg, valium for sale online in Australia

Symptoms: Ataxia, drowsiness, dysarthria, sedation, muscle weakness, profound sleep, hypotension, restlessness, nystagmus, confusion. Severe cases may lead to ataxia, cardiorespiratory depression, coma, and very rarely, death. Management: Supportive and symptomatic treatment. Initiate IV fluids administration, adequate ventilation and clear airway. Administration of activated charcoal may be given within 1 hour of ingestion. If hypotension occurs, raise foot of the bed and give appropriate fluid; administer α-adrenergic agents such as norepinephrine to decrease systemic vascular resistance. Flumazenil may be used for the complete or partial reversal of the sedative effects provided that necessary measures in initial supportive treatment is established. Buy Apo Diazepam 5mg, valium for sale online in Australia