Contents. Buy Targin online, oxycodone hydrochloride for sale in Australia
Oxycodone hydrochloride, naloxone hydrochloride.
Description
Targin 5 mg/2.5 mg: Each prolonged-release tablet contains 5 mg of oxycodone hydrochloride equivalent to 4.5 mg oxycodone, and 2.73 mg of naloxone hydrochloride dihydrate equivalent to 2.5 mg naloxone hydrochloride and 2.25 mg naloxone.
Targin 10 mg/5 mg: Each prolonged-release tablet contains 10 mg of oxycodone hydrochloride equivalent to 9.0 mg oxycodone, and 5.45 mg of naloxone hydrochloride dihydrate equivalent to 5.0 mg naloxone hydrochloride and 4.5 mg naloxone. Buy Targin online, oxycodone hydrochloride for sale in Australia
Targin 20 mg/10 mg: Each prolonged-release tablet contains 20 mg of oxycodone hydrochloride equivalent to 18.0 mg oxycodone, and 10.9 mg of naloxone hydrochloride dihydrate equivalent to 10.0 mg naloxone hydrochloride and 9.0 mg naloxone.
Targin 40 mg/20 mg: Each prolonged-release tablet contains 40 mg of oxycodone hydrochloride equivalent to 36.0 mg oxycodone, and 21.8 mg of naloxone hydrochloride dihydrate equivalent to 20.0 mg naloxone hydrochloride and 18.0 mg naloxone.
Excipients/Inactive Ingredients: lactose anhydrous (68.17 mg, 61.04 mg, 51.78 mg or 103.55 mg, respectively)
Tablet core: Ethylcellulose, Stearyl alcohol, Lactose monohydrate, Talc, Magnesium stearate. Targin 5 mg/2.5 mg: Hydroxypropylcellulose. Targin 10 mg/5 mg, 20 mg/10 mg, 40 mg/20 mg: Povidone K30. Buy Targin online, oxycodone hydrochloride for sale in Australia
Tablet coat: Poly(vinylalcohol), Titanium dioxide (E171), Macrogol 3350, Talc. Targin 5 mg/2.5 mg: Brilliant Blue FCF aluminium lake (E133). Targin 20 mg/10 mg: Iron oxide red (E172). Targin 40 mg/20 mg: Iron oxide yellow (E172).
Targin 10 mg/5 mg: Each prolonged-release tablet contains 10 mg of oxycodone hydrochloride equivalent to 9.0 mg oxycodone, and 5.45 mg of naloxone hydrochloride dihydrate equivalent to 5.0 mg naloxone hydrochloride and 4.5 mg naloxone. Buy Targin online, oxycodone hydrochloride for sale in Australia
Targin 20 mg/10 mg: Each prolonged-release tablet contains 20 mg of oxycodone hydrochloride equivalent to 18.0 mg oxycodone, and 10.9 mg of naloxone hydrochloride dihydrate equivalent to 10.0 mg naloxone hydrochloride and 9.0 mg naloxone.
Targin 40 mg/20 mg: Each prolonged-release tablet contains 40 mg of oxycodone hydrochloride equivalent to 36.0 mg oxycodone, and 21.8 mg of naloxone hydrochloride dihydrate equivalent to 20.0 mg naloxone hydrochloride and 18.0 mg naloxone.
Excipients/Inactive Ingredients: lactose anhydrous (68.17 mg, 61.04 mg, 51.78 mg or 103.55 mg, respectively)
Tablet core: Ethylcellulose, Stearyl alcohol, Lactose monohydrate, Talc, Magnesium stearate. Targin 5 mg/2.5 mg: Hydroxypropylcellulose. Targin 10 mg/5 mg, 20 mg/10 mg, 40 mg/20 mg: Povidone K30. Buy Targin online, oxycodone hydrochloride for sale in Australia
Tablet coat: Poly(vinylalcohol), Titanium dioxide (E171), Macrogol 3350, Talc. Targin 5 mg/2.5 mg: Brilliant Blue FCF aluminium lake (E133). Targin 20 mg/10 mg: Iron oxide red (E172). Targin 40 mg/20 mg: Iron oxide yellow (E172).
Indications/Uses
The management of moderate to severe chronic pain unresponsive to non-opioid analgesics. The opioid antagonist naloxone is added to counteract opioid-induced constipation by blocking the action of oxycodone at opioid receptors locally in the gut.
Dosage/Direction for Use
Targin is for oral use. Buy Targin online, oxycodone hydrochloride for sale in Australia
Posology: The analgesic efficacy of Targin is equivalent to oxycodone hydrochloride prolonged-release formulations.
The dosage should be adjusted to the intensity of pain and the sensitivity of the individual patient. Unless otherwise prescribed, Targin should be administered as follows: Adults: The usual starting dose for an opioid naïve patient is 10 mg/5 mg of oxycodone hydrochloride/naloxone hydrochloride at 12 hourly intervals.
Lower strengths are available to facilitate dose titration when initiating opioid therapy and for individual dose adjustment.
Patients already receiving opioids may be started on higher doses of Targin depending on their previous opioid experience.
Targin 5 mg/2.5 mg is intended for dose titration when initiating opioid therapy and individual dose adjustment. Buy Targin online, oxycodone hydrochloride for sale in Australia
The maximum daily dose of Targin is 160 mg oxycodone hydrochloride and 80 mg naloxone hydrochloride. The maximum daily dose is reserved for patients who have previously been maintained on a stable daily dose of Targin and who have become in need of an increased dose. Special attention should be given to patients with compromised renal function and patients with mild hepatic impairment if an increased dose is considered. For patients requiring higher doses of Targin, administration of supplemental oxycodone hydrochloride prolonged-release at the same time intervals should be considered, taking into account the maximum daily dose of 400 mg prolonged-release oxycodone hydrochloride. In the case of supplemental oxycodone hydrochloride dosing, the beneficial effect of naloxone hydrochloride on bowel function may be impaired. After complete discontinuation of therapy with Targin with a subsequent switch to another opioid a worsening of the bowel function can be expected. Buy Targin online, oxycodone hydrochloride for sale in Australia
Some patients taking Targin according to a regular time schedule require immediate-release analgesics as “rescue” medication for breakthrough pain. Targin is a prolonged-release formulation and therefore not intended for the treatment of breakthrough pain. For the treatment of breakthrough pain, a single dose of “rescue medication” should approximate one sixth of the equivalent daily dose of oxycodone hydrochloride. The need for more than two “rescues” per day is usually an indication that the dose of Targin requires upward adjustment. This adjustment should be made every 1-2 days in steps of twice daily 5 mg/2.5 mg, or where necessary 10 mg/5 mg, oxycodone hydrochloride/naloxone hydrochloride until a stable dose is reached. The aim is to establish a patient-specific twice daily dose that will maintain adequate analgesia and make use of as little rescue medication as possible for as long as pain therapy is necessary. Buy Targin online, oxycodone hydrochloride for sale in Australia
A single dose of Targin greater than 40 mg/20 mg or a total daily dose greater than 80 mg/40 mg is only for use in patients in whom tolerance to an opioid of comparable potency has been established.
Patients considered opioid tolerant are those receiving, for one week or longer, at least 60 mg oral morphine/day, 25 mcg transdermal fentanyl/hour, 30 mg oral oxycodone/day, 8 mg oral hydromorphone/day, 25 mg oral oxymorphone/day, or an equianalgesic dose of another opioid.
Targin is taken at the determined dosage twice daily according to a fixed time schedule. While symmetric administration (the same dose mornings and evenings) subject to a fixed time schedule (every 12 hours) is appropriate for the majority of patients, some patients, depending on the individual pain situation, may benefit from asymmetric dosing tailored to their pain pattern. In general, the lowest effective analgesic dose should be selected.
In non-malignant pain therapy, daily doses of up to 40 mg/20 mg oxycodone hydrochloride/naloxone hydrochloride are usually sufficient, but higher doses may be needed. Buy Targin online, oxycodone hydrochloride for sale in Australia
For doses not realisable/practicable with this strength other strengths of this medicinal product are available.
Children and adolescents (under 18 years): Targin is not recommended for use in children and adolescents below the age of 18 years due to a lack of data on safety and efficacy. Buy Targin online, oxycodone hydrochloride for sale in Australia
Elderly patients: As for younger adults the dosage should be adjusted to the intensity of the pain and the sensitivity of the individual patient.
Posology: The analgesic efficacy of Targin is equivalent to oxycodone hydrochloride prolonged-release formulations.
The dosage should be adjusted to the intensity of pain and the sensitivity of the individual patient. Unless otherwise prescribed, Targin should be administered as follows: Adults: The usual starting dose for an opioid naïve patient is 10 mg/5 mg of oxycodone hydrochloride/naloxone hydrochloride at 12 hourly intervals.
Lower strengths are available to facilitate dose titration when initiating opioid therapy and for individual dose adjustment.
Patients already receiving opioids may be started on higher doses of Targin depending on their previous opioid experience.
Targin 5 mg/2.5 mg is intended for dose titration when initiating opioid therapy and individual dose adjustment. Buy Targin online, oxycodone hydrochloride for sale in Australia
The maximum daily dose of Targin is 160 mg oxycodone hydrochloride and 80 mg naloxone hydrochloride. The maximum daily dose is reserved for patients who have previously been maintained on a stable daily dose of Targin and who have become in need of an increased dose. Special attention should be given to patients with compromised renal function and patients with mild hepatic impairment if an increased dose is considered. For patients requiring higher doses of Targin, administration of supplemental oxycodone hydrochloride prolonged-release at the same time intervals should be considered, taking into account the maximum daily dose of 400 mg prolonged-release oxycodone hydrochloride. In the case of supplemental oxycodone hydrochloride dosing, the beneficial effect of naloxone hydrochloride on bowel function may be impaired. After complete discontinuation of therapy with Targin with a subsequent switch to another opioid a worsening of the bowel function can be expected. Buy Targin online, oxycodone hydrochloride for sale in Australia
Some patients taking Targin according to a regular time schedule require immediate-release analgesics as “rescue” medication for breakthrough pain. Targin is a prolonged-release formulation and therefore not intended for the treatment of breakthrough pain. For the treatment of breakthrough pain, a single dose of “rescue medication” should approximate one sixth of the equivalent daily dose of oxycodone hydrochloride. The need for more than two “rescues” per day is usually an indication that the dose of Targin requires upward adjustment. This adjustment should be made every 1-2 days in steps of twice daily 5 mg/2.5 mg, or where necessary 10 mg/5 mg, oxycodone hydrochloride/naloxone hydrochloride until a stable dose is reached. The aim is to establish a patient-specific twice daily dose that will maintain adequate analgesia and make use of as little rescue medication as possible for as long as pain therapy is necessary. Buy Targin online, oxycodone hydrochloride for sale in Australia
A single dose of Targin greater than 40 mg/20 mg or a total daily dose greater than 80 mg/40 mg is only for use in patients in whom tolerance to an opioid of comparable potency has been established.
Patients considered opioid tolerant are those receiving, for one week or longer, at least 60 mg oral morphine/day, 25 mcg transdermal fentanyl/hour, 30 mg oral oxycodone/day, 8 mg oral hydromorphone/day, 25 mg oral oxymorphone/day, or an equianalgesic dose of another opioid.
Targin is taken at the determined dosage twice daily according to a fixed time schedule. While symmetric administration (the same dose mornings and evenings) subject to a fixed time schedule (every 12 hours) is appropriate for the majority of patients, some patients, depending on the individual pain situation, may benefit from asymmetric dosing tailored to their pain pattern. In general, the lowest effective analgesic dose should be selected.
In non-malignant pain therapy, daily doses of up to 40 mg/20 mg oxycodone hydrochloride/naloxone hydrochloride are usually sufficient, but higher doses may be needed. Buy Targin online, oxycodone hydrochloride for sale in Australia
For doses not realisable/practicable with this strength other strengths of this medicinal product are available.
Children and adolescents (under 18 years): Targin is not recommended for use in children and adolescents below the age of 18 years due to a lack of data on safety and efficacy. Buy Targin online, oxycodone hydrochloride for sale in Australia
Elderly patients: As for younger adults the dosage should be adjusted to the intensity of the pain and the sensitivity of the individual patient.
| Quantity | 84 Tablets (3 box), 168 Tablets (6 box), 336 Tablets (12 box) |
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