Description
Each nasal spray device contains esketamine hydrochloride corresponding to 28 mg esketamine. Where to buy legal esketamine, Ketamine Nasal Spray for sale online in Australia
Excipients/Inactive Ingredients: Citric acid monohydrate, Disodium edetate, Sodium hydroxide (for pH adjustment), Water for injections.
Action
Pharmacotherapeutic group: Psychoanaleptics; Other antidepressants. ATC code: N06AX27.
Pharmacology: Pharmacodynamics: Mechanism of action: Esketamine is the S-enantiomer of racemic ketamine. It is a non-selective, non-competitive, antagonist of the N-methyl-D-aspartate (NMDA) receptor, an ionotropic glutamate receptor. Through NMDA receptor antagonism, esketamine produces a transient increase in glutamate release leading to increases in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) stimulation and subsequently to increases in neurotrophic signalling which may contribute to the restoration of synaptic function in these brain regions involved with the regulation of mood and emotional behaviour. Restoration of dopaminergic neurotransmission in brain regions involved in the reward and motivation, and decreased stimulation of brain regions involved in anhedonia, may contribute to the rapid response. Where to buy legal esketamine, Ketamine Nasal Spray for sale online in Australia
Pharmacology: Pharmacodynamics: Mechanism of action: Esketamine is the S-enantiomer of racemic ketamine. It is a non-selective, non-competitive, antagonist of the N-methyl-D-aspartate (NMDA) receptor, an ionotropic glutamate receptor. Through NMDA receptor antagonism, esketamine produces a transient increase in glutamate release leading to increases in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) stimulation and subsequently to increases in neurotrophic signalling which may contribute to the restoration of synaptic function in these brain regions involved with the regulation of mood and emotional behaviour. Restoration of dopaminergic neurotransmission in brain regions involved in the reward and motivation, and decreased stimulation of brain regions involved in anhedonia, may contribute to the rapid response. Where to buy legal esketamine, Ketamine Nasal Spray for sale online in Australia
Indications/Uses
SPRAVATO, in combination with a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI), is indicated for adults with treatment-resistant Major Depressive Disorder (MDD), who have not responded to at least two different treatments with antidepressants in the current moderate to severe depressive episode (see Pharmacology: Pharmacodynamics under Actions).
SPRAVATO is indicated, in conjunction with an oral antidepressant, for the treatment of depressive symptoms in adults with MDD with acute suicidal ideation or behavior. Where to buy legal esketamine, Ketamine Nasal Spray for sale online in Australia
Limitations of Use: The effectiveness of SPRAVATO in preventing suicide or in reducing suicidal ideation or behavior has not been demonstrated (see Pharmacology: Pharmacodynamics under Actions). Use of SPRAVATO does not preclude the need for hospitalization if clinically warranted, even if patients experience improvement after an initial dose of SPRAVATO.
SPRAVATO is not approved as an anesthetic agent. The safety and effectiveness of SPRAVATO as an anesthetic agent have not been established.
SPRAVATO is indicated, in conjunction with an oral antidepressant, for the treatment of depressive symptoms in adults with MDD with acute suicidal ideation or behavior. Where to buy legal esketamine, Ketamine Nasal Spray for sale online in Australia
Limitations of Use: The effectiveness of SPRAVATO in preventing suicide or in reducing suicidal ideation or behavior has not been demonstrated (see Pharmacology: Pharmacodynamics under Actions). Use of SPRAVATO does not preclude the need for hospitalization if clinically warranted, even if patients experience improvement after an initial dose of SPRAVATO.
SPRAVATO is not approved as an anesthetic agent. The safety and effectiveness of SPRAVATO as an anesthetic agent have not been established.
Dosage/Direction for Use Where to buy legal esketamine, Ketamine Nasal Spray for sale online in Australia
The decision to prescribe SPRAVATO should be determined by a psychiatrist.
SPRAVATO is intended to be self-administered by the patient under the direct supervision of a healthcare professional.
A treatment session consists of nasal administration of SPRAVATO and a post-administration observation period. Both administration and post-administration observation of SPRAVATO should be carried out in an appropriate clinical setting.
Assessment before treatment: Prior to dosing with SPRAVATO blood pressure should be assessed.
If baseline blood pressure is elevated the risks of short-term increases in blood pressure and benefit of SPRAVATO treatment should be considered (see Precautions). SPRAVATO should not be administered if an increase in blood pressure or intracranial pressure poses a serious risk (see Contraindications). Where to buy legal esketamine, Ketamine Nasal Spray for sale online in Australia
Patients with clinically significant or unstable cardiovascular or respiratory conditions require additional precautions. In these patients, SPRAVATO should be administered in a setting where appropriate resuscitation equipment and healthcare professionals with training in cardiopulmonary resuscitation are available (see Precautions).
Post-administration observation: After dosing with SPRAVATO, blood pressure should be reassessed at approximately 40 minutes and subsequently as clinically warranted (see Precautions).
Because of the possibility of sedation, dissociation and elevated blood pressure, patients must be monitored by a healthcare professional until the patient is considered clinically stable and ready to leave the healthcare setting (see Precautions). Where to buy legal esketamine, Ketamine Nasal Spray for sale online in Australia
SPRAVATO is intended to be self-administered by the patient under the direct supervision of a healthcare professional.
A treatment session consists of nasal administration of SPRAVATO and a post-administration observation period. Both administration and post-administration observation of SPRAVATO should be carried out in an appropriate clinical setting.
Assessment before treatment: Prior to dosing with SPRAVATO blood pressure should be assessed.
If baseline blood pressure is elevated the risks of short-term increases in blood pressure and benefit of SPRAVATO treatment should be considered (see Precautions). SPRAVATO should not be administered if an increase in blood pressure or intracranial pressure poses a serious risk (see Contraindications). Where to buy legal esketamine, Ketamine Nasal Spray for sale online in Australia
Patients with clinically significant or unstable cardiovascular or respiratory conditions require additional precautions. In these patients, SPRAVATO should be administered in a setting where appropriate resuscitation equipment and healthcare professionals with training in cardiopulmonary resuscitation are available (see Precautions).
Post-administration observation: After dosing with SPRAVATO, blood pressure should be reassessed at approximately 40 minutes and subsequently as clinically warranted (see Precautions).
Because of the possibility of sedation, dissociation and elevated blood pressure, patients must be monitored by a healthcare professional until the patient is considered clinically stable and ready to leave the healthcare setting (see Precautions). Where to buy legal esketamine, Ketamine Nasal Spray for sale online in Australia
| Quantity | 10 Sprays, 20 Sprays, 50 Sprays |
|---|
Be the first to review “Buy Ketamine Nasal Spray”
Related products
Anti Depression
Price range: $300.00 through $800.00
Anti Depression
Price range: $250.00 through $800.00
Anti Depression
Price range: $250.00 through $800.00
Anti Depression
Price range: $270.00 through $700.00
Reviews
There are no reviews yet.