Buy Alprax 2 (Alprazolam) online

Oral
Short-term management of anxiety

Oral
Panic disorder with or without agoraphobia

Debilitated patients: As conventional tab, orally-disintegrating tab, oral solution: 0.25 mg 2-3 times daily, may be increased gradually if needed and tolerated. As extended-release tab: Initially, 0.5 mg once daily, may be increased gradually if needed and tolerated. Buy Alprax 2, Alprazolam 2mg for sale online in Australia

Severe: Contraindicated.

May be taken with or without food. Side effects eg, sleepiness/drowsiness may be reduced if taken immediately after meals.

Myasthenia gravis, severe respiratory insufficiency, sleep apnoea syndrome, acute narrow-angle glaucoma. Severe hepatic impairment. Concomitant use with potent CYP3A4 inhibitors (e.g. ketoconazole, itraconazole).

Patients with depression, suicidal tendencies, psychiatric or personality disorder, respiratory disease, history of drug abuse or acute alcoholism. Patients who are debilitated, obese, smokers, or at risk of falls. Concomitant use with opioids. Avoid abrupt withdrawal. Renal and mild to moderate hepatic impairment. Elderly. Pregnancy and lactation. Buy Alprax 2, Alprazolam 2mg for sale online in Australia

Significant: Suicidal ideation, CNS depression, anterograde amnesia, psychiatric and paradoxical reactions, interdose symptoms (e.g. early morning anxiety, breakthrough anxiety), sleep-related activities (e.g. sleep-driving, cooking, eating or making phone calls while asleep), tolerance, abuse, psychological and physical dependence; rebound or withdrawal symptoms including seizures.
Cardiac disorders: Palpitations, chest pain.
Endocrine disorders: Hyperprolactinaemia.
Eye disorders: Blurred vision.
Gastrointestinal disorders: Constipation, dry mouth, nausea, vomiting, increased salivation.
General disorders and admin site conditions: Ataxia, lethargy, fatigue, irritability.
Hepatobiliary disorders: Jaundice, abnormal hepatic function, hepatitis.
Investigations: Weight increased or decreased, increased intraocular pressure.
Metabolism and nutrition disorders: Decreased or increased appetite. Buy Alprax 2, Alprazolam 2mg for sale online in Australia
Musculoskeletal and connective tissue disorders: Muscle weakness, arthralgia, myalgia.
Nervous system disorders: Sedation, somnolence, headache, dizziness, memory impairment, balance disorder, abnormal coordination, tremor.
Psychiatric disorders: Depression, insomnia, confusional state, anxiety, disorientation, nervousness, dysarthria, disturbance in attention, hypersomnia, decreased or increased libido.
Renal and urinary disorders: Incontinence, difficulty in micturition.
Reproductive system and breast disorders: Sexual dysfunction, irregular menstruation.
Respiratory, thoracic and mediastinal disorders: Nasal congestion, dyspnoea, rhinitis.
Skin and subcutaneous tissue disorders: Dermatitis, rash, pruritus.
Vascular disorders: Hypotension. Buy Alprax 2, Alprazolam 2mg for sale online in Australia

PO: D

This drug may cause drowsiness, sedation, amnesia, impaired concentration or muscle function, if affected, do not drive or operate machinery.

Monitor CV and respiratory status.

Symptoms: Somnolence, confusion, impaired coordination, diminished reflexes, coma and death. Management: Symptomatic and supportive treatment. Induce vomiting within 1 hour of ingestion if the patient is conscious or consider gastric lavage with protected airway if the patient is unconscious. May administer activated charcoal to reduce absorption if there is no advantage in gastric emptying. Flumazenil may be given as an antidote. Buy Alprax 2, Alprazolam 2mg for sale online in Australia

Enhanced CNS depressant effects with other anxiolytics or sedatives, antipsychotics (neuroleptics), hypnotics, antidepressants, narcotic analgesics, antiepileptic drugs, anaesthetics, sedative antihistamines. Increased plasma concentrations with CYP3A4 inhibitors (e.g. nefazodone, fluvoxamine, cimetidine, fluoxetine, propoxyphene, oral contraceptives, sertraline, paroxetine, diltiazem, isoniazid, macrolide antibiotics such as erythromycin, clarithromycin, troleandomycin). May enhance metabolism with CYP3A4 inducers (e.g. ritonavir, carbamazepine). May increase plasma concentrations of digoxin.
Potentially Fatal: Enhanced CNS depressant effects of opioids. Increased plasma concentrations with potent CYP3A4 inhibitors (e.g. ketoconazole, itraconazole and other azole-type antifungals). Buy Alprax 2, Alprazolam 2mg for sale online in Australia

Enhanced CNS depressant effects with alcohol. May increase bioavailability with grapefruit juice.

Description: Alprazolam binds to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron at several sites within the CNS, including the limbic system and reticular formation. Enhancement of the GABA inhibitory effect on neuronal excitability results by increased neuronal membrane permeability to Cl ions, which results in hyperpolarisation (a less excitable state) and stabilisation. Benzodiazepine receptors and effects appear to be linked to the GABA-A receptors but does not bind to GABA-B receptors.
Pharmacokinetics:
Absorption: Readily absorbed from the gastrointestinal tract. Bioavailability: 84-92% (immediate-release tab); 90% (extended-release tab). Time to peak plasma concentration: 1-2 hours (immediate-release tab); approx 9 hours (extended-release tab); 1.5-2 hours (orally-disintegrating tab). Buy Alprax 2, Alprazolam 2mg for sale online in Australia
Distribution: Crosses placenta and enters breast milk. Volume of distribution: 0.84-1.42 L/kg (immediate-release tab). Plasma protein binding: Approx 80%, mainly to albumin.
Metabolism: Extensively metabolised in the liver by CYP3A4 isoenzyme into α-hydroxyalprazolam and 4-hydroxyalprazolam metabolites, and an inactive benzophenone metabolite.
Excretion: Via urine (as unchanged drug and metabolites). Elimination half-life: 11.2 hours; 6.3-26.9 hours (immediate-release tab); 10.7-15.8 hours (extended-release tab); 12.5 hours (orally-disintegrating tab). Buy Alprax 2, Alprazolam 2mg for sale online in Australia